Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
نویسندگان
چکیده
منابع مشابه
Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
PURPOSE Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR. Matrix metalloproteinases (MMPs) constitute a family of Zn-dependent endopeptidases that can decompose the extracellular matrix and basement membrane, and regulate cell infiltration. We analyzed the expression of MMPs and their inhibitors, tissue inhibitors of metallop...
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Background Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR as compared to asthma and also that in nasal polyps. Matrix metalloproteinases (MMPs) can decompose the extracellular matrix and regulate cell infiltration. In order to understand the role of MMPs in AR, we analyzed the expression of MMPs and their inhibitors, tissue...
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Chronic exposure to crystalline silica particles results in macrophagelymphocytic granulomatous lung inflammation, which is followed by abnormal and progressive accumulation of extracellular matrix. 1,2 However, the pathogenic mechanisms and the sequence of the pathological events leading to the fibrotic response have not been well defined. In this context, there is evidence suggesting an upreg...
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INTRODUCTION Tissue inhibitors of metalloproteinases (TIMP) and the matrix metalloproteinases (MMP) are involved in the spread of cancer. METHODS We have evaluated the matrix metalloproteinases' (MMP-10, MMP-7) and their inhibitors' (tissue inhibitors of metalloproteinases - TIMP-1, TIMP-2) mRNA expression in 61 esophageal cancer samples from patients who had undergone surgery, by using real-...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Immunology Research
سال: 2012
ISSN: 2092-7355,2092-7363
DOI: 10.4168/aair.2012.4.4.231